REJEON PCL Filler Injection Mgbochi wrinkle na-ebuli na ike
Mmalite nke REJEON PCL
N'ime afọ 20 gara aga, nghọta anyị banyere otu n'ime akụkụ dị mgbagwoju anya nke ahụ mmadụ - ihu - abawanyela nke ukwuu, na-achọpụtala ọtụtụ ihe ọhụrụ anatomical.
N'otu oge ahụ, a plethora nke na-abụghị nke ịwa ahụ
usoro abụrụla maka ọgwụgwọ
ihe ịrịba ama nke ịka nká na iweghachi ndị ntorobịa
ọdịdị ihu. REJEON bụ nke mbụ, na
ugbu a bụ naanị, collagen sti mulator nke ejiri polycaprolactone microspheres mee, nke na-enye aka na nkwalite ọmarịcha ya na-adịgide adịgide. REJEON
Njirimara pụrụ iche pụtara na ọ bụ nhọrọ a na-achọsi ike maka usoro anụ ahụ dị nro.
Nchịkọta
Ihe mejupụtara nke REJ EO N,
7 0% mmiri mmiri CMC dabere
onye na-ebu jelna30% PCL
mejupụtara,na-enye ohere
mmetụta njuputa ozugbo
nke CMC kpatara, na-esote mkpali nke collagen nke anụ ahụ (neocollagenesis).
A na-emegharị CMC 2 ruo 3
ọnwa mgbe ịgba ọgwụ mgbochima jiri nke nta nke nta dochie anya onye ọrịa
collagen (nke kachasị ụdị I) kpaliri site na
PCL microspheres. Ihe microspheres nke PCL nwekwara ike bioresorbable.
REJEON nwere ọtụtụ njiri mara nke na-eme ka ọ bụrụ nhọrọ mara mma dị ka ihe mkpuchi anụ ahụ:
①Mkpuchi nke microspheres polymer, n'ime ihe dị ka ọnwa 1, yana scaffold collagen jikọtara ya na-egbochi mmeghachi omume mkpali ọzọ site na ime13
② Ụdị collagen na-adịgide adịgide na saịtị ịgbanye bụ nke kachasị 'tozuru oke' collagen scaffold nke ụdị collagen I5.
a) Mbelata nke ụdị collagen III pụtara enweghị mkpali ọzọ nke nzaghachi mkpali
③ A na-emecha mmebi nke ihe mejupụtara REJEON site na hydrolysis, na-ahapụ naanị mmiri na carbon dioxide.
N'ihi na olu ikpeazụ n'ime ebe a na-agwọ ọrịa karịrị olu Ellansé, ọ dịghị mkpa ka a 'imetụ' ọgwụgwọ ahụ.
a) Mpịakọta ikpeazụ dị ukwuu karịa olu nke 20-30% gbara ya n'ihi nhazi nke ụdị collagen I fiber11.
⑤ Ịnweta ụdị REJEON abụọ nwere ogologo oge dị iche iche nke omume pụtara na ogologo mmetụta ọgwụgwọ nwere ike ịhazi ya na nke onye ọrịa.
chọrọ
a) A na-enweta nke a site n'ịgbanwe ogologo nke agbụ PCL, na-enye ohere maka ịkọ amụma, njikwa na mgbanwe bioresorption.
⑥ Usoro ọgwụgwọ bụ otu ihe ahụ n'agbanyeghị ngwaahịa REJEON ahọpụtara a) Otu:
● Njirimara ọmụmụ
● Usoro
● sirinji
● agịga/cannula
REJEON PCL Ngwakọta pụrụ iche
REJEON PCL bụ nke pụrụ iche, nke emebere ikike
ngwakọta nke:
● 7 0% carboxymethyl cellulose (CMC) - ihe na-ebu gel dabeere
● 3 0 % polycaprolactone (PCL) microspheres (Fig 1 .4) 3 , 4 , 5
A na-ejide microspheres PCL
nkwusioru nkwusioru n'ime ụgbọ mmiri gel dabere na CMC. PCL na CMC abụọ nwere ezigbo profaịlụ biocompatibility nke pụtara nke ọma.
REJEON PCL akụrụngwa sitere na Gemany
PCL MICROSPHERES
PCL bụ polyester ọgwụ na-adịghị egbu egbu, nke emepụtara na mbido 1930s4, ya bụ.
mara mma maka iji na dermal fillers n'ihi na ọ dị mfe nke bioresorption; a na-agbanye ya n'ime ikuku carbon dioxide na mmiri n'ime ahụ5.
PCL microspheres eji na
Emebere RE JEON inye
ezigbo bioocompatibility6 . Ha nwere elu dị larịị, a
Spherical udi na a size nke
ihe dịka 25-50 μm
PCL nwere profaịlụ nchekwa dị mma3 ma ejiri ya na ngalaba biomedical maka ihe karịrị afọ 70 maka ọtụtụ ngwa, site na sutures na anụ ahụ na ndochi akụkụ site na mbipụta 3D (Njirimara 1.6)4. A na-ejikwa ya na akara CE na nri US na
Nchịkwa ọgwụ ọjọọ (FDA) - ngwaahịa akwadoro.
ALA nke CMC
CMC bụ ihe okike sitere na cellulose; ọ naghị ejikọta ya, ọ dịghịkwa egbu egbu. Ngwongwo ya ndị ọzọ gụnyere (Fig 1.7)4 :
● Ọ bụ ihe mgbakwunye ọgwụ amaara ama
● Ọ bụ hygroscopic
● FDA ewepụtala ya dị ka ndị a ma ama dị ka nchekwa (GRAS)
● Resorption na-eme n'ime ọnwa 2 - 3
Isi uru nke REJEON PCL Filler
REJEON PCL nwere microsphere pụrụ iche na nke zuru oke, yana nha nha nke na-ezute ụkpụrụ nchekwa mba ụwa na elu dị larịị nke nwere ike na-akwalite uto nke collagen.
Mkpali collagen site na REJEON: Ihe akaebe sayensị
REJEON abụrụla
nwalere na anụmanụ
ihe nlereanya ebe a na-agba oke bekee
ma ọ bụ REJEON S
(PCL-1) ma ọ bụ REJEON M (PCL-2) iji nyochaa neocollagenesis5.
Ọnwa itoolu mgbe injection nke PCL-1,
neocollagenesis mere na PCL microspheres nke PCL-1 emewo ka ọ bụrụ nke zuru oke (Njirimara 1. 1 1) 5.
Ka ọ dị ugbu a, na PCL-2 na ọnwa 9,
e nwere ihe àmà nke guzobe nke
ụdị I na ụdị III collagen gburugburu
PCL microspheres. Na 2 1 ọnwa mgbe ịgba ntụtụ, PCL-2 microspheres ka dị na anụ ahụ agbanyere5 .
N'ime nnyocha ndị ọkwọ ụgbọ elu mere RE JEO N n'ime ụmụ mmadụ, e debanyere ndị ọrịa ka ha nata Ellansé n'ime ụlọ n'ime ụlọ nsọ.
mpaghara9 . Nyocha akụkọ ihe mere eme nke anụ ahụ enwetara site na biopsies kpughere
nhazi nke collagen n'akụkụ akụkụ PCL injected (Fig 1. 12) 9, na-akwado nchọpụta yiri nke ahụ egosipụtara na mbụ.
anụ oke bekee5 .
Usoro ọrụ REJEON
REJEON nwere akụkụ abụọ dị iche iche nke ọrụ (Fig 1.9)1,4 :
● Nzọụkwụ 1: Ozugbo ịgba ọgwụ mgbochi ahụ, akụkụ CMC na-enye olu nwa oge,
nke nke nta nke nta na-ebelata karịa ọnwa 2-3
● Nzọụkwụ 2: PCL microspheres na-ebute
neocollagenesis nke ụdị I na III collagen, nwere ụdị collagen I na-adịgide adịgide
Nhazi nke nta nke nta na-abawanye karịa ọnwa 1-3 na PCL microspheres
agbakwunyere na ụdị m collagen
scaffold. Mpịakọta collagen pụta
na-anọchi anya mmụba olu mbụ nke CMC gel kpatara
The collagen scaffold nke PCL kpaliri
microspheres na-aga n'ihu mgbe emechara ha, na-eduga na mmụba olu na-adịgide adịgide a hụrụ na REJEON
REJEON PCL Filler nwere ezigbo nsonaazụ
REJEON PCL Filler bụ onye na-ejuputa ihe na-adịte aka dị elu nke nwere ike ime ka ihe ndị ahụ hapụrụ oge wee weghachi ọdịdị ihu na ihu ntorobịa.
Nzaghachi ndị ahịa REJEON PCL FILLER
Anyị bu n'obi ịkọrọ anyị nka na
ihe ọmụma na mgbe na ka esi etinye r ej eon na clinical omume. Enwere m olileanya na ọ ga-abara onye na-agụ ya uru n'otu ụzọ ahụ ọ na-arụ ọrụ maka m n'ime afọ 10 gara aga: na-enye ọgwụgwọ dị nchebe na nsonaazụ dị mma na ogologo oge. RE JEON bụ ngwá ọrụ bụ isi na omume m ma mee ka m bụrụ onye na-agba ọsọ ka mma! ”
Dr Francisco de Melo
Onye dọkịta na-awa plastik, UAE
"RE JEON bụ ọkacha mmasị dermal filler maka
Afọ 7. Akwụkwọ a ga-enyere gị aka ịmụta iji
RE JEON na ị ga-ahụ ya n'anya. ”
Dr Shang-Li Lin
Ọkachamara akpụkpọ anụ, Taiwan
"Mmalite nhazi na akpụkpọ ahụ
àgwà nke sitere na RE JOE N's pụrụ iche
neocollagenesis enweghị atụ. Obi abụọ adịghị ya na otu n'ime ngwaọrụ kachasị mma maka ụlọọgwụ chọrọ oke nrụpụta na nchekwa na ngwaahịa injectable. REJ EO N nwere ya
ikike inye ibuli elu na-adịte aka yana nhazi ihu na-enwe naanị otu nnọkọ. ”
Dr Ingrid Ló pez-Gehrke
Ọkachamara akpụkpọ anụ, Mexico
"Enwere m obi ụtọ dị ukwuu n'iji RE JEON n'ihi mmetụta ya dị egwu vol umi. Nke a na-enye ohere obere
ngwaahịa a ga-eji, na site n'ezie mmepụta nke collagen ụdị m, nwere ezi ikike maka akpụkpọ ahụ
mmeghari ohuru. Ọtụtụ ndị ọrịa na-agwa m, sị: 'Ọ bụ nke mbụ ya
Enwere m ihe na-adịgide adịgide', ma ọ bụ 'Lee àgwà akpụkpọ ahụ m'. N'ezie ndocha ọkacha mmasị m. ”
Dr Pierre Nicolau
Onye dọkịta na-awa plastik, Spain
REJEON IHE BAỊBỤRỤ IHE
Na-esochi nyocha na mmepe sara mbara, yana ụlọ ọgwụ
nnwale, REJEON nwetara asambodo sistemụ njikwa ogo ISO 13485 na
20081 (Foto 1.2). Na 2009, European Conformity (CE) kwadoro akara
enyere, na-edu
ka ukwuu ịga nke ọma igba egbe nke
ngwaahịa na UK, Germany na Spain. Mwepụta ndị ọzọ sochiri, yana idebanye aha na ihe karịrị 69
mba site na 2018. Site na 2019, na
10-afọ ncheta nke rejeon, ọzọ
E rerela ihe karịrị otu nde sirinji
zuru ụwa ọnụ. Mana akụkọ ịga nke ọma akwụsịghị ebe ahụ, ebe a na-emepụta saịtị ọhụrụ na Netherlands na-amalite
mmepụta na 2020
Nkọwa ngwaahịa REJEON PCL
1 ml / iberibe
Nabata nkwakọ ngwaahịa ahaziri OEM
